An indolent pancreatic ductal adenocarcinoma with psammoma bodies and a coincidental neuroendocrine tumor

Abstract

Pancreatic ductal adenocarcinoma is a very aggressive neoplasm with a low survival rate, comprising the majority of pancreatic malignancies. Psammoma bodies have rarely been reported in pancreatic ductal adenocarcinoma, and their clinicopathologic significance is unclear. In this report we will discuss a case of a very slow-growing pancreatic ductal adenocarcinoma arising in the neck/body with a coincidental neuroendocrine tumor in the tail. Prominent psammoma bodies are observed in the ductal carcinoma (absent in the neuroendocrine tumor). The presence of psammoma bodies within an indolent pancreatic ductal adenocarcinoma is very unusual and suggests a possible association with a favorable clinical course. Further study would be warranted to make a firm conclusion. Keywords: Pancreatic ductal adenocarcinoma, Psammoma bodies, Hyaline globules, Neuroendocrine tumor