Nature Communications (Aug 2018)

Molecular insights into antibiotic resistance - how a binding protein traps albicidin

  • Lida Rostock,
  • Ronja Driller,
  • Stefan Grätz,
  • Dennis Kerwat,
  • Leonard von Eckardstein,
  • Daniel Petras,
  • Maria Kunert,
  • Claudia Alings,
  • Franz-Josef Schmitt,
  • Thomas Friedrich,
  • Markus C. Wahl,
  • Bernhard Loll,
  • Andi Mainz,
  • Roderich D. Süssmuth

DOI
https://doi.org/10.1038/s41467-018-05551-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella oxytoca.