Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

Abstract

Autophagy is a cellular process for recycling cell constituents, and is essential for T cell activation, but its function in T cell polarization is still unclear. Here the authors show that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and antitumour immunity.