Bayesian Generalized Linear Mixed Modeling of Breast Cancer

Abstract

Background: Breast cancer is one of the most common cancers among women. Breast cancer treatment strategies in Nigeria need urgent strengthening to reduce mortality rate because of the disease. This study aimed to determine the relationship between the ages at diagnosis and established the prognostic factors of modality of treatment given to breast cancer patient in Nigeria. Methods: The data was collected for 247 women between years 2011-2015 who had breast cancer in two different hospitals in Ekiti State, Nigeria. Model estimation is based on Bayesian approach via Markov Chain Monte Carlo. A multilevel model based on generalized linear mixed model is used to estimate the random effect. Results: The mean age of the patients (at the time of diagnosis) was 42.2 yr with 52% of the women aged between 35-49 yr. The results of the two approaches are almost similar but preference is given to Bayesian because the approach is more robust than the frequentist. Significant factors of treatment modality are age, educational level and breast cancer type. Conclusion: Differences in socio-demographic factors such as educational level and age at diagnosis significantly influence the modality of breast cancer treatment in western Nigeria. The study suggests the use of Bayesian multilevel approach in analyzing breast cancer data for the practicality, flexibility and strength of the method.

Keywords

• Bayesian
• Breast cancer
• Multilevel
• Generalized linear mixed modeling
• CODA/BOA