Frontiers in Cardiovascular Medicine (Nov 2021)
Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives
- Jianning Zhang,
- Jianning Zhang,
- Jianning Zhang,
- Jiawen Liang,
- Jiawen Liang,
- Jiawen Liang,
- Xiaoyu Zhang,
- Xiaoyu Zhang,
- Xiaoyu Zhang,
- Chen Su,
- Chen Su,
- Chen Su,
- Jiang He,
- Jiang He,
- Jiang He,
- Yumin Qiu,
- Yumin Qiu,
- Yumin Qiu,
- Zhe Zhou,
- Zhe Zhou,
- Zhe Zhou,
- Zhichao Wang,
- Zhichao Wang,
- Zhichao Wang,
- Bing Dong,
- Bing Dong,
- Bing Dong,
- Qiang Tu,
- Qiang Tu,
- Qiang Tu,
- Shiyue Xu,
- Shiyue Xu,
- Shiyue Xu,
- Wenhao Xia,
- Wenhao Xia,
- Wenhao Xia,
- Jun Tao,
- Jun Tao,
- Jun Tao
Affiliations
- Jianning Zhang
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jianning Zhang
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jianning Zhang
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiawen Liang
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiawen Liang
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiawen Liang
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Xiaoyu Zhang
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Xiaoyu Zhang
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Xiaoyu Zhang
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Chen Su
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Chen Su
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Chen Su
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiang He
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiang He
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiang He
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Yumin Qiu
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Yumin Qiu
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Yumin Qiu
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zhe Zhou
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zhe Zhou
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zhe Zhou
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zhichao Wang
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zhichao Wang
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zhichao Wang
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Bing Dong
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Bing Dong
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Bing Dong
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Qiang Tu
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Qiang Tu
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Qiang Tu
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Shiyue Xu
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Shiyue Xu
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Shiyue Xu
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Wenhao Xia
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Wenhao Xia
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Wenhao Xia
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jun Tao
- Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jun Tao
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jun Tao
- Key Laboratory on Assisted Circulation of Ministry of Health, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fcvm.2021.744349
- Journal volume & issue
-
Vol. 8
Abstract
Vascular dysfunction is a key hallmark of hypertension and related cardiovascular outcomes. As a well-known hemodynamic disease, hypertension is characterized by abnormal ventricular-vascular interactions. Complementing non-invasive systemic hemodynamics in hypertensive vascular risk assessment is of promising significance. We aimed to investigate the effects of abnormal hemodynamic states other than elevated blood pressure on vascular damage and establish a united index of systemic hemodynamics for generalized vascular risk evaluation. Non-invasive systemic hemodynamics, assessed by impedance cardiography, was compared among blood pressure stages. Vascular function was evaluated by flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (baPWV). Systemic hemodynamics was obtained from a total of 88 enrollees with a mean (±SD) systolic blood pressure 140 (±17) mm Hg, and aged 17 to 91 years. Both stroke systemic vascular resistance index and left stroke work index exhibited a significant alteration among blood pressure stages (p < 0.001; p = 0.01, respectively), whereas heterogeneous hemodynamic and vascular function subsets existed within similar blood pressure. In addition, blood pressure categories failed to recognize between-group differences in endothelial dysfunction (p = 0.88) and arterial stiffness (p = 0.26). An increase in myocardial contractility and a parallel decrease in afterload was associated with the decline of vascular dysfunction. Systemic Hemodynamic Index (SHI), as a surrogate marker, demonstrated a significantly negative correlation with vascular damage index (VDI, r = −0.49, p < 0.001). These findings illustrate that systemic hemodynamics underlying hypertensives provides more vascular information. The SHI/VDI score may be a feasible tool for cardiovascular function assessment.
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