Journal of Pharmacological Sciences (Jan 2003)

Nafamostat Mesilate Is an Extremely Potent Inhibitor of Human Tryptase

  • Shuji Mori,
  • Yoshinori Itoh,
  • Ryoko Shinohata,
  • Toshiaki Sendo,
  • Ryozo Oishi,
  • Masahiro Nishibori

DOI
https://doi.org/10.1254/s1347-8613(19)32641-6
Journal volume & issue
Vol. 92, no. 4
pp. 420 – 423

Abstract

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Previously, nafamostat mesilate was found to be a potent inhibitor of human tryptase. In present study, we performed a kinetic study to determine its Ki value for tryptase and compared it with that of gabexate mesilate. Nafamostat mesilate inhibited human tryptase in a competitive manner. The apparent Ki value was estimated to be 95.3 pM, which was 1,000 times lower than that of gabexate mesilate (95.1 nM). These results strongly indicated that nafamostat mesilate is an extremely potent inhibitor of tryptase and suggested that some of its beneficial effects in the treatment of clinical status may be due to tryptase inhibition.