The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population

Abstract

PURPOSE Although attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim of the present study was to investigate the association between ADHD and RELN gene in Turkish children. METHOD DNA samples were harvested from 102 patients with ADHD and 94 healthy controls. Three single-nucleotide polymorphisms of reelin gene (rs1270519, rs362691, and rs734147) were genotyped using real-time polymerase chain reaction. RESULTS A significant difference was detected between ADHD and control groups regarding rs1270519 polymorphism while no significant difference was detected between the groups regarding reelin rs362691 and rs734147 polymorphisms. CONCLUSION It was found that reelin rs12705169 gene polymorphism could play a role in ADHD etiology, indicating the need for further studies to investigate the relationship between ADHD and reelin gene polymorphism.

Keywords

• Attention deficit hyperactivity disorder
• reelin
• polymorphism