Nature Communications (Oct 2022)
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity
- Miriam Rosás-Umbert,
- Jesper D. Gunst,
- Marie H. Pahus,
- Rikke Olesen,
- Mariane Schleimann,
- Paul W. Denton,
- Victor Ramos,
- Adam Ward,
- Natalie N. Kinloch,
- Dennis C. Copertino,
- Tuixent Escribà,
- Anuska Llano,
- Zabrina L. Brumme,
- R. Brad Jones,
- Beatriz Mothe,
- Christian Brander,
- Julie Fox,
- Michel C. Nussenzweig,
- Sarah Fidler,
- Marina Caskey,
- Martin Tolstrup,
- Ole S. Søgaard
Affiliations
- Miriam Rosás-Umbert
- Department of Clinical Medicine, Aarhus University
- Jesper D. Gunst
- Department of Clinical Medicine, Aarhus University
- Marie H. Pahus
- Department of Clinical Medicine, Aarhus University
- Rikke Olesen
- Department of Clinical Medicine, Aarhus University
- Mariane Schleimann
- Department of Infectious Diseases, Aarhus University Hospital
- Paul W. Denton
- Department of Biology, University of Nebraska at Omaha
- Victor Ramos
- Laboratory of Molecular Immunology, The Rockefeller University
- Adam Ward
- Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College
- Natalie N. Kinloch
- Faculty of Health Sciences, Simon Fraser University
- Dennis C. Copertino
- Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College
- Tuixent Escribà
- IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol
- Anuska Llano
- IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol
- Zabrina L. Brumme
- Faculty of Health Sciences, Simon Fraser University
- R. Brad Jones
- Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College
- Beatriz Mothe
- IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol
- Christian Brander
- IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol
- Julie Fox
- Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas’ National Health Service Trust
- Michel C. Nussenzweig
- Laboratory of Molecular Immunology, The Rockefeller University
- Sarah Fidler
- Department of Infectious Diseases, Imperial College London
- Marina Caskey
- Laboratory of Molecular Immunology, The Rockefeller University
- Martin Tolstrup
- Department of Clinical Medicine, Aarhus University
- Ole S. Søgaard
- Department of Clinical Medicine, Aarhus University
- DOI
- https://doi.org/10.1038/s41467-022-34171-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Broadly neutralising anti-HIV-1 antibody (bNAb) administration in nonhuman primates has been shown to stimulate adaptive T cell-specific immunity, with infection prevention observed. In this work, the authors longitudinally analyse HIV-1 specific cellular immunity in HIV-1- infected individuals starting ART with or without adjunctive bNAb treatment.
