Nature Communications (Dec 2022)
Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats
- Jesus Paez-Mayorga,
- Jocelyn Nikita Campa-Carranza,
- Simone Capuani,
- Nathanael Hernandez,
- Hsuan-Chen Liu,
- Corrine Ying Xuan Chua,
- Fernanda Paola Pons-Faudoa,
- Gulsah Malgir,
- Bella Alvarez,
- Jean A. Niles,
- Lissenya B. Argueta,
- Kathryn A. Shelton,
- Sarah Kezar,
- Pramod N. Nehete,
- Dora M. Berman,
- Melissa A. Willman,
- Xian C. Li,
- Camillo Ricordi,
- Joan E. Nichols,
- A. Osama Gaber,
- Norma S. Kenyon,
- Alessandro Grattoni
Affiliations
- Jesus Paez-Mayorga
- Department of Nanomedicine, Houston Methodist Research Institute
- Jocelyn Nikita Campa-Carranza
- Department of Nanomedicine, Houston Methodist Research Institute
- Simone Capuani
- Department of Nanomedicine, Houston Methodist Research Institute
- Nathanael Hernandez
- Department of Nanomedicine, Houston Methodist Research Institute
- Hsuan-Chen Liu
- Department of Nanomedicine, Houston Methodist Research Institute
- Corrine Ying Xuan Chua
- Department of Nanomedicine, Houston Methodist Research Institute
- Fernanda Paola Pons-Faudoa
- Department of Nanomedicine, Houston Methodist Research Institute
- Gulsah Malgir
- Department of Nanomedicine, Houston Methodist Research Institute
- Bella Alvarez
- Department of Nanomedicine, Houston Methodist Research Institute
- Jean A. Niles
- Center for Tissue Engineering, Houston Methodist Research Institute
- Lissenya B. Argueta
- Center for Tissue Engineering, Houston Methodist Research Institute
- Kathryn A. Shelton
- Department of Comparative Medicine, Michael E. Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center
- Sarah Kezar
- Department of Comparative Medicine, Michael E. Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center
- Pramod N. Nehete
- Department of Comparative Medicine, Michael E. Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center
- Dora M. Berman
- Diabetes Research Institute, University of Miami
- Melissa A. Willman
- Diabetes Research Institute, University of Miami
- Xian C. Li
- Department of Surgery, Houston Methodist Hospital
- Camillo Ricordi
- Diabetes Research Institute, University of Miami
- Joan E. Nichols
- Center for Tissue Engineering, Houston Methodist Research Institute
- A. Osama Gaber
- Department of Surgery, Houston Methodist Hospital
- Norma S. Kenyon
- Diabetes Research Institute, University of Miami
- Alessandro Grattoni
- Department of Nanomedicine, Houston Methodist Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-35629-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Islet transplantation for type 1 diabetes management is hindered by the life-long need for immunosuppressive medications. Here, the authors report an islet encapsulation device with local anti-rejection drug release that achieves long-term diabetes reversal in male rats and reduces drug-related toxicity.
