Nature Communications (Jul 2022)
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance
- Jiliang Xia,
- Jingyu Zhang,
- Xuan Wu,
- Wanqing Du,
- Yinghong Zhu,
- Xing Liu,
- Zhenhao Liu,
- Bin Meng,
- Jiaojiao Guo,
- Qin Yang,
- Yihui Wang,
- Qinglin Wang,
- Xiangling Feng,
- Guoxiang Xie,
- Yi Shen,
- Yanjuan He,
- Juanjuan Xiang,
- Minghua Wu,
- Gang An,
- Lugui Qiu,
- Wei Jia,
- Wen Zhou
Affiliations
- Jiliang Xia
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Jingyu Zhang
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Xuan Wu
- Cancer Research Institute, School of Basic Medical Sciences, Central South University
- Wanqing Du
- Xiangya School of Public Health, Central South University
- Yinghong Zhu
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Xing Liu
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Zhenhao Liu
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Bin Meng
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Jiaojiao Guo
- Cancer Research Institute, School of Basic Medical Sciences, Central South University
- Qin Yang
- Department of Hematology, Third Xiangya Hospital, Central South University
- Yihui Wang
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Qinglin Wang
- Department of Laboratory Medicine, Hunan Normal University School of Medicine
- Xiangling Feng
- Xiangya School of Public Health, Central South University
- Guoxiang Xie
- Human Metabolomics Institute, Inc
- Yi Shen
- Department of Orthopaedic Surgery, Second Xiangya Hospital, Central South University
- Yanjuan He
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- Juanjuan Xiang
- Cancer Research Institute, School of Basic Medical Sciences, Central South University
- Minghua Wu
- Cancer Research Institute, School of Basic Medical Sciences, Central South University
- Gang An
- State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College
- Lugui Qiu
- State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College
- Wei Jia
- School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong
- Wen Zhou
- Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of Hematology, Xiangya Hospital, Central South University
- DOI
- https://doi.org/10.1038/s41467-022-31248-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The bone tumour microenvironment plays an essential role in multiple myeloma (MM) development. Here, the authors show that bone collagen degradation provides glycine to support MM progression through glutathione and purine synthesis.
