Nature Communications (Jul 2021)

Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation

  • He Sun,
  • Xinlu Zhu,
  • Chuanxi Li,
  • Zhiming Ma,
  • Xiao Han,
  • Yuanyuan Luo,
  • Liang Yang,
  • Jing Yu,
  • Yansong Miao

DOI
https://doi.org/10.1038/s41467-021-24375-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Bacterial pathogens can subvert host cell processes through secreted proteins but the precise mechanisms and repertoire of proteins remains unclear. Here the authors report that a bacterial effector protein of Xanthomonas campestris, XopR, undergoes liquid-liquid phase separation to hijack the host cell actin cytoskeleton.