Polyamine Derived Photosensitizer: A Novel Approach for Photodynamic Therapy of Cancer
Hao Deng,
Ke Xie,
Liling Hu,
Xiaowen Liu,
Qingyun Li,
Donghui Xie,
Fengyi Xiang,
Wei Liu,
Weihong Zheng,
Shuzhang Xiao,
Jun Zheng,
Xiao Tan
Affiliations
Hao Deng
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Ke Xie
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Liling Hu
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China
Xiaowen Liu
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Qingyun Li
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Donghui Xie
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Fengyi Xiang
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Wei Liu
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China
Weihong Zheng
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Shuzhang Xiao
College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
Jun Zheng
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China
Xiao Tan
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Polyamines play a pivotal role in cancer cell proliferation. The excessive polyamine requirement of these malignancies is satisfied through heightened biosynthesis and augmented extracellular uptake via the polyamine transport system (PTS) present on the cell membrane. Meanwhile, photodynamic therapy (PDT) emerges as an effective anti-cancer treatment devoid of drug resistance. Recognizing these intricacies, our study devised a novel polyamine-derived photosensitizer (PS) for targeted photodynamic treatment, focusing predominantly on pancreatic cancer cells. We synthesized and evaluated novel spermine-derived fluorescent probes (N2) and PS (N3), exhibiting selectivity towards pancreatic cancer cells via PTS. N3 showed minimal dark toxicity but significant phototoxicity upon irradiation, effectively causing cell death in vitro. A significant reduction in tumor volume was observed post-treatment with no pronounced dark toxicity using the pancreatic cancer CDX mouse model, affirming the therapeutic potential of N3. Overall, our findings introduce a promising new strategy for cancer treatment, highlighting the potential of polyamine-derived PSs in PDT.
