Nature Communications (Mar 2020)

Nanocrystal facet modulation to enhance transferrin binding and cellular delivery

  • Yu Qi,
  • Tong Zhang,
  • Chuanyong Jing,
  • Sijin Liu,
  • Chengdong Zhang,
  • Pedro J. J. Alvarez,
  • Wei Chen

DOI
https://doi.org/10.1038/s41467-020-14972-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Modulation of exposed crystal facets enhances transferrin binding to chalcogenide nanocrystals and their subsequent delivery into cancer cells. Facet-dependent protein binding occurs through inner-sphere thiol complexation and is affected by the structure of the first solvation shell.