Archives of Endocrinology and Metabolism ()

The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus

  • Karla Simone Costa de Souza,
  • Marcela Abbott Galvão Ururahy,
  • Yonara Monique da Costa Oliveira,
  • Melina Bezerra Loureiro,
  • Heglayne Pereira Vital da Silva,
  • Raul Hernandes Bortolin,
  • André Ducati Luchessi,
  • Ricardo Fernando Arrais,
  • Rosário Dominguez Crespo Hirata,
  • Maria das Graças Almeida,
  • Mário Hiroyuki Hirata,
  • Adriana Augusto de Rezende

DOI
https://doi.org/10.20945/2359-3997000000057
Journal volume & issue
Vol. 62, no. 4
pp. 480 – 484

Abstract

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ABSTRACT Objective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. Subjects and methods: A total number of 134 T1DM patients and 180 normoglycemic individuals (NG) aged 6-20 years were studied. Glycated hemoglobin and glucose levels were determined. Genotyping of LRP5 4037C>T (rs3736228) was performed. Results: T1DM patients showed poor glycemic control. Genotypes in the codominant (CT: OR = 2.99 [CI 95%: 1.71-5.24], p T may represent a candidate for T1DM susceptibility, as well as poor glycemic control.

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