Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission

Sarah L. White, PhD; William Rawlinson, FRACP, FRCPA, PhD; Peter Boan, FRACP, FRCPA; Vicky Sheppeard, FAFPHM; Germaine Wong, FRACP, PhD; Karen Waller, MBBS; Helen Opdam, FRACP, FCICM; John Kaldor, PhD; Michael Fink, MD, FRACS; Deborah Verran, MD, FRACS; Angela Webster, PhD, FRCP, FRACP; Kate Wyburn, FRACP, PhD; Lindsay Grayson, MD, FRACP, FAFPHM, FRCP, FIDSA; Allan Glanville, MD, FRACP; Nick Cross, MD, PhD; Ashley Irish, FRACP; Toby Coates, FRACP, PhD; Anthony Griffin, FRACS; Greg Snell, MD, FRACP; Stephen I. Alexander, MD, FRACP; Scott Campbell, FRACP, PhD; Steven Chadban, FRACP, PhD; Peter Macdonald, MD, FRACP, PhD; Paul Manley, FRACP; Eva Mehakovic; Vidya Ramachandran, MBBS; Alicia Mitchell, PhD; Michael Ison, MD

doi:10.1097/TXD.0000000000000852

Transplantation Direct (Jan 2019)

Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission

Sarah L. White, PhD,
William Rawlinson, FRACP, FRCPA, PhD,
Peter Boan, FRACP, FRCPA,
Vicky Sheppeard, FAFPHM,
Germaine Wong, FRACP, PhD,
Karen Waller, MBBS,
Helen Opdam, FRACP, FCICM,
John Kaldor, PhD,
Michael Fink, MD, FRACS,
Deborah Verran, MD, FRACS,
Angela Webster, PhD, FRCP, FRACP,
Kate Wyburn, FRACP, PhD,
Lindsay Grayson, MD, FRACP, FAFPHM, FRCP, FIDSA,
Allan Glanville, MD, FRACP,
Nick Cross, MD, PhD,
Ashley Irish, FRACP,
Toby Coates, FRACP, PhD,
Anthony Griffin, FRACS,
Greg Snell, MD, FRACP,
Stephen I. Alexander, MD, FRACP,
Scott Campbell, FRACP, PhD,
Steven Chadban, FRACP, PhD,
Peter Macdonald, MD, FRACP, PhD,
Paul Manley, FRACP,
Eva Mehakovic,
Vidya Ramachandran, MBBS,
Alicia Mitchell, PhD,
Michael Ison, MD

Affiliations

Sarah L. White, PhD: 1 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.
William Rawlinson, FRACP, FRCPA, PhD: 2 Serology and Virology Division, NSW Health Pathology Prince of Wales Hospital, Sydney, Australia.
Peter Boan, FRACP, FRCPA: 4 Departments of Infectious Diseases and Microbiology, Fiona Stanley Hospital, Perth, Australia.
Vicky Sheppeard, FAFPHM: 6 Communicable Diseases Network Australia, New South Wales Health, Sydney, Australia.
Germaine Wong, FRACP, PhD: 7 Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia.
Karen Waller, MBBS: 1 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.
Helen Opdam, FRACP, FCICM: 10 Austin Health, Melbourne, Australia.
John Kaldor, PhD: 12 Kirby Institute, University of New South Wales, Sydney, Australia.
Michael Fink, MD, FRACS: 10 Austin Health, Melbourne, Australia.
Deborah Verran, MD, FRACS: 14 Transplantation Services, Royal Prince Alfred Hospital, Sydney, Australia.
Angela Webster, PhD, FRCP, FRACP: 7 Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia.
Kate Wyburn, FRACP, PhD: 1 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.
Lindsay Grayson, MD, FRACP, FAFPHM, FRCP, FIDSA: 10 Austin Health, Melbourne, Australia.
Allan Glanville, MD, FRACP: 16 Department of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Sydney, Australia.
Nick Cross, MD, PhD: 17 Department of Nephrology, Canterbury District Health Board, Christchurch Hospital, Christchurch, New Zealand.
Ashley Irish, FRACP: 18 Department of Nephrology, Fiona Stanley Hospital, Perth, Australia.
Toby Coates, FRACP, PhD: 20 Renal and Transplantation, Royal Adelaide Hospital, Adelaide, Australia.
Anthony Griffin, FRACS: 22 Renal Transplantation, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Greg Snell, MD, FRACP: 23 Lung Transplant, Alfred Health, Melbourne, Victoria, Australia.
Stephen I. Alexander, MD, FRACP: 8 Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Scott Campbell, FRACP, PhD: 24 Department of Renal Medicine, University of Queensland at Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Steven Chadban, FRACP, PhD: 1 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.
Peter Macdonald, MD, FRACP, PhD: 25 Department of Cardiology, St Vincent's Hospital, Sydney, Australia.
Paul Manley, FRACP: 27 Kidney Disorders, Auckland District Health Board, Auckland City Hospital, Auckland, New Zealand.
Eva Mehakovic: 11 The Organ and Tissue Authority, Australian Government, Canberra, Australia.
Vidya Ramachandran, MBBS: 2 Serology and Virology Division, NSW Health Pathology Prince of Wales Hospital, Sydney, Australia.
Alicia Mitchell, PhD: 16 Department of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Sydney, Australia.
Michael Ison, MD: 30 Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL.

DOI: https://doi.org/10.1097/TXD.0000000000000852
Journal volume & issue: Vol. 5, no. 1
p. e416

Abstract

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Abstract. In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.

Published in Transplantation Direct

ISSN: 2373-8731 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: http://journals.lww.com/transplantationdirect/Pages/default.aspx

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