Nature Communications (Jun 2020)
Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy
- Kuan Hu,
- Lin Xie,
- Yiding Zhang,
- Masayuki Hanyu,
- Zhimin Yang,
- Kotaro Nagatsu,
- Hisashi Suzuki,
- Jiang Ouyang,
- Xiaoyuan Ji,
- Junjie Wei,
- Hao Xu,
- Omid C. Farokhzad,
- Steven H. Liang,
- Lu Wang,
- Wei Tao,
- Ming-Rong Zhang
Affiliations
- Kuan Hu
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Lin Xie
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Yiding Zhang
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Masayuki Hanyu
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Zhimin Yang
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Kotaro Nagatsu
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Hisashi Suzuki
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Jiang Ouyang
- Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School
- Xiaoyuan Ji
- Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School
- Junjie Wei
- Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University
- Hao Xu
- Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University
- Omid C. Farokhzad
- Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School
- Steven H. Liang
- Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Harvard Medical School
- Lu Wang
- Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University
- Wei Tao
- Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School
- Ming-Rong Zhang
- Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- DOI
- https://doi.org/10.1038/s41467-020-16513-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
A balance between high stability and rapid degradation is required for effective photothermal anti-cancer agents. Here, the authors use Cu2+ to accelerate the degradation of black phosphorus nanosheets while enhancing its photothermal ability and apply this material for PET-guided, CDT-enhanced combination cancer therapy in mice.
