Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology

C. Wittenbecher; R. Cuadrat; L. Johnston; F. Eichelmann; S. Jäger; O. Kuxhaus; M. Prada; F. Del Greco M.; A. A. Hicks; P. Hoffman; J. Krumsiek; F. B. Hu; M. B. Schulze

doi:10.1038/s41467-022-28496-1

Nature Communications (Feb 2022)

Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology

C. Wittenbecher,
R. Cuadrat,
L. Johnston,
F. Eichelmann,
S. Jäger,
O. Kuxhaus,
M. Prada,
F. Del Greco M.,
A. A. Hicks,
P. Hoffman,
J. Krumsiek,
F. B. Hu,
M. B. Schulze

Affiliations

C. Wittenbecher: Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
R. Cuadrat: Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
L. Johnston: Steno Diabetes Center Aarhus
F. Eichelmann: Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
S. Jäger: Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
O. Kuxhaus: Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
M. Prada: Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
F. Del Greco M.: Institute for Biomedicine, Eurac Research, Bolzano/Bozen, Italy, affiliated with the University of Lübeck
A. A. Hicks: Institute for Biomedicine, Eurac Research, Bolzano/Bozen, Italy, affiliated with the University of Lübeck
P. Hoffman: Human Genomics Research Group, Department of Biomedicine, University of Basel
J. Krumsiek: Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Department of Physiology and Biophysics, Weill Cornell Medicine
F. B. Hu: Department of Nutrition, Harvard T.H. Chan School of Public Health
M. B. Schulze: Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke

DOI: https://doi.org/10.1038/s41467-022-28496-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Among lipid classes, ceramides are linked to impaired cardiometabolic health. Here the authors report the association of specific ceramides and dihydroceramides on the risk of developing type 2 diabetes and or cardiovascular disease in a prospective population cohort.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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