Nature Communications (Aug 2022)

Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning

  • Ruben van den Bosch,
  • Britt Lambregts,
  • Jessica Määttä,
  • Lieke Hofmans,
  • Danae Papadopetraki,
  • Andrew Westbrook,
  • Robbert-Jan Verkes,
  • Jan Booij,
  • Roshan Cools

DOI
https://doi.org/10.1038/s41467-022-32679-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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The mechanisms underpinning the variability in methylphenidate’s effects on cognition remain unclear. Here, the authors show that such effects reflect changes in striatal dopamine-related output gating of task-relevant cortical signals, and that these changes depend on baseline dopamine synthesis capacity.