Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic

Deepak Kumar; Rishabha Malviya; Shriyansh Srivastava; Sathvik Belagodu Sridhar; Sirajunisa Talath; Javedh Shareef; Bhupendra G. Prajapati

Infectious Medicine (Mar 2025)

Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic

Deepak Kumar,
Rishabha Malviya,
Shriyansh Srivastava,
Sathvik Belagodu Sridhar,
Sirajunisa Talath,
Javedh Shareef,
Bhupendra G. Prajapati

Affiliations

Deepak Kumar: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India
Rishabha Malviya: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India; Galgotias Multi-Disciplinary Research & Development Cell (G-MRDC), Galgotias University, Greater Noida-201308, U.P., India; Corresponding author.
Shriyansh Srivastava: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India; Corresponding author.
Sathvik Belagodu Sridhar: RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras al Khaimah 11172, United Arab Emirates
Sirajunisa Talath: RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras al Khaimah 11172, United Arab Emirates
Javedh Shareef: RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras al Khaimah 11172, United Arab Emirates
Bhupendra G. Prajapati: Department of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana 384012, India

Journal volume & issue: Vol. 4, no. 1
p. 100166

Abstract

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Mpox, formerly known as monkeypox, is a zoonotic virus of the Orthopoxvirus genus, with recent outbreaks of Clade I and Ib in Central Africa presenting a considerable global health threat. This study reviews current Mpox immunization approaches, focusing on the MVA-BN, LC16-KMB, and OrthopoxVac vaccines. MVA-BN vaccination has been successful in lowering infection risks, particularly in high-risk individuals and is widely used in the USA. LC16-KMB is recommended by the World Health Organization for prevention in afflicted regions. OrthopoxVac, a newer vaccination authorized in Russia, provides wide protection. Adapting vaccination approaches based on epidemiology in particular areas is critical for minimizing Mpox outbreaks.

Published in Infectious Medicine

ISSN: 2772-431X (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.journals.elsevier.com/infectious-medicine

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Abstract

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