Analysis of Outpatient Prescription Trends of Non-Narcotic Analgesics and Proton Pump Inhibitors (PPIs) in Taiwan from 2010 to 2021: A Nationwide Population-Based Study

Abstract

The purpose of this study is to describe the prevalence, trends, and associations of the use of outpatient prescription non-narcotic analgesics and proton pump inhibitors (PPIs) in Taiwan from 2010 to 2021. We identified the most commonly prescribed analgesics and PPIs, including paracetamol (acetaminophen) and nonsteroidal anti-inflammatory drugs (NSAIDs), in outpatient departments according to the data from Taiwan National Health Insurance Research Database and Taiwan’s NHI Annual Statistical Report. This study shows that the traditional non-selective NSAIDs take the largest proportion of usage, representing over 60% of the annual usage of non-narcotic analgesics. Acetaminophen is the second and takes over 30% of annual usage. The selective COX-2 (coxibs) takes less than 10% of usage, but its use is growing rapidly. This study also shows that the annual usage of PPIs is growing rapidly and is not decreasing with the use of selective COX-2. The findings in this study can help us to focus on the most commonly prescribed drugs to investigate the prescription pattern of NSAIDs and PPIs, especially the combined use of selective COX-2 and PPIs, in future study.

Keywords

• non-narcotic analgesics
• acetaminophen
• nonsteroidal anti-inflammatory drugs (NSAIDs)
• selective COX-2
• proton pump inhibitors (PPIs)