RUDN Journal of Medicine (Jun 2012)

Genetic polymorphisms and effecacy of antivital therapy ofchronic viral hepatitis C

  • L I Nikolaeva,
  • Е I Sамоkhvalov,
  • S V Al'khovskiy,
  • A V Kolotvin,
  • L М Samokhodskaya,
  • V V Makashova,
  • A К Тokmalaev

Journal volume & issue
Vol. 0, no. 2
pp. 81 – 88

Abstract

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Aim: to determine influence of genetic polymorphisms of hepatitis C virus and single nucleotide polymorphisms (SNPs) of patients with chronic hepatitis C on achieving sustained virological response (SVR) to antiviral therapy. One hundred blood samples of eastern-Slavonic patients with different response to the therapy were analyzed. It was determined, that among SNPs of 7 human genes only allelic variants of IL-1β, IL-28B, TGF-β1 and viral genotypes can influence on probability to achieve SVR.

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