iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2

Iqbal Dulloo; Peace Atakpa-Adaji; Yi-Chun Yeh; Clémence Levet; Sonia Muliyil; Fangfang Lu; Colin W. Taylor; Matthew Freeman

doi:10.1038/s41467-022-28930-4

Nature Communications (Mar 2022)

iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2

Iqbal Dulloo,
Peace Atakpa-Adaji,
Yi-Chun Yeh,
Clémence Levet,
Sonia Muliyil,
Fangfang Lu,
Colin W. Taylor,
Matthew Freeman

Affiliations

Iqbal Dulloo: Dunn School of Pathology, University of Oxford
Peace Atakpa-Adaji: Department of Pharmacology, University of Cambridge
Yi-Chun Yeh: Department of Physiology, Anatomy and Genetics, University of Oxford
Clémence Levet: Dunn School of Pathology, University of Oxford
Sonia Muliyil: Dunn School of Pathology, University of Oxford
Fangfang Lu: Dunn School of Pathology, University of Oxford
Colin W. Taylor: Department of Pharmacology, University of Cambridge
Matthew Freeman: Dunn School of Pathology, University of Oxford

DOI: https://doi.org/10.1038/s41467-022-28930-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Cells that cannot cope with persistent endoplasmic reticulum stress will die. Here, the authors show that iRhom pseudoproteases regulate cell death by modulating the ability of BCL-2 to inhibit calcium flow through IP3R channels.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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