Nature Communications (Mar 2016)
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
- Johannes Kettunen,
- Ayşe Demirkan,
- Peter Würtz,
- Harmen H.M. Draisma,
- Toomas Haller,
- Rajesh Rawal,
- Anika Vaarhorst,
- Antti J. Kangas,
- Leo-Pekka Lyytikäinen,
- Matti Pirinen,
- René Pool,
- Antti-Pekka Sarin,
- Pasi Soininen,
- Taru Tukiainen,
- Qin Wang,
- Mika Tiainen,
- Tuulia Tynkkynen,
- Najaf Amin,
- Tanja Zeller,
- Marian Beekman,
- Joris Deelen,
- Ko Willems van Dijk,
- Tõnu Esko,
- Jouke-Jan Hottenga,
- Elisabeth M van Leeuwen,
- Terho Lehtimäki,
- Evelin Mihailov,
- Richard J. Rose,
- Anton J.M. de Craen,
- Christian Gieger,
- Mika Kähönen,
- Markus Perola,
- Stefan Blankenberg,
- Markku J. Savolainen,
- Aswin Verhoeven,
- Jorma Viikari,
- Gonneke Willemsen,
- Dorret I. Boomsma,
- Cornelia M. van Duijn,
- Johan Eriksson,
- Antti Jula,
- Marjo-Riitta Järvelin,
- Jaakko Kaprio,
- Andres Metspalu,
- Olli Raitakari,
- Veikko Salomaa,
- P. Eline Slagboom,
- Melanie Waldenberger,
- Samuli Ripatti,
- Mika Ala-Korpela
Affiliations
- Johannes Kettunen
- Computational Medicine, Faculty of Medicine, University of Oulu
- Ayşe Demirkan
- Department of Human Genetics, Leiden University Medical Center
- Peter Würtz
- Computational Medicine, Faculty of Medicine, University of Oulu
- Harmen H.M. Draisma
- Department of Biological Psychology, VU University Amsterdam
- Toomas Haller
- Estonian Genome Center, University of Tartu
- Rajesh Rawal
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München
- Anika Vaarhorst
- Department of Molecular Epidemiology, Leiden University Medical Center
- Antti J. Kangas
- Computational Medicine, Faculty of Medicine, University of Oulu
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere University
- Matti Pirinen
- Institute for Molecular Medicine (FIMM), University of Helsinki
- René Pool
- Department of Biological Psychology, VU University Amsterdam
- Antti-Pekka Sarin
- National Institute for Health and Welfare
- Pasi Soininen
- Computational Medicine, Faculty of Medicine, University of Oulu
- Taru Tukiainen
- Department of Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Qin Wang
- Computational Medicine, Faculty of Medicine, University of Oulu
- Mika Tiainen
- Computational Medicine, Faculty of Medicine, University of Oulu
- Tuulia Tynkkynen
- Computational Medicine, Faculty of Medicine, University of Oulu
- Najaf Amin
- Department of Epidemiology, Erasmus Medical Center
- Tanja Zeller
- German Center for Cardiovascular Research (DZHK e.V.)
- Marian Beekman
- Department of Molecular Epidemiology, Leiden University Medical Center
- Joris Deelen
- Department of Molecular Epidemiology, Leiden University Medical Center
- Ko Willems van Dijk
- Department of Human Genetics, Leiden University Medical Center
- Tõnu Esko
- Estonian Genome Center, University of Tartu
- Jouke-Jan Hottenga
- Department of Biological Psychology, VU University Amsterdam
- Elisabeth M van Leeuwen
- Department of Epidemiology, Erasmus Medical Center
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere University
- Evelin Mihailov
- Estonian Genome Center, University of Tartu
- Richard J. Rose
- Department of Public Health, Hjelt Institute, University of Helsinki
- Anton J.M. de Craen
- Department of Geriatrics and Gerontology, Leiden University Medical Center
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München
- Mika Kähönen
- Department of Clinical Physiology, University of Tampere and Tampere, University Hospital
- Markus Perola
- National Institute for Health and Welfare
- Stefan Blankenberg
- German Center for Cardiovascular Research (DZHK e.V.)
- Markku J. Savolainen
- Biocenter Oulu, University of Oulu
- Aswin Verhoeven
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Jorma Viikari
- Department of Medicine, University of Turku and Turku University Hospital
- Gonneke Willemsen
- Department of Biological Psychology, VU University Amsterdam
- Dorret I. Boomsma
- Department of Biological Psychology, VU University Amsterdam
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus Medical Center
- Johan Eriksson
- National Institute for Health and Welfare
- Antti Jula
- National Institute for Health and Welfare
- Marjo-Riitta Järvelin
- Biocenter Oulu, University of Oulu
- Jaakko Kaprio
- Institute for Molecular Medicine (FIMM), University of Helsinki
- Andres Metspalu
- Estonian Genome Center, University of Tartu
- Olli Raitakari
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Veikko Salomaa
- National Institute for Health and Welfare
- P. Eline Slagboom
- Department of Molecular Epidemiology, Leiden University Medical Center
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München
- Samuli Ripatti
- National Institute for Health and Welfare
- Mika Ala-Korpela
- Computational Medicine, Faculty of Medicine, University of Oulu
- DOI
- https://doi.org/10.1038/ncomms11122
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a).
