Nature Communications (Jan 2020)
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
- D. H. Wilson,
- E. J. Jarman,
- R. P. Mellin,
- M. L. Wilson,
- S. H. Waddell,
- P. Tsokkou,
- N. T. Younger,
- A. Raven,
- S. R. Bhalla,
- A. T. R. Noll,
- S. W. Olde Damink,
- F. G. Schaap,
- P. Chen,
- D. O. Bates,
- J. M. Banales,
- C. H. Dean,
- D. J. Henderson,
- O. J. Sansom,
- T. J. Kendall,
- L. Boulter
Affiliations
- D. H. Wilson
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- E. J. Jarman
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- R. P. Mellin
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- M. L. Wilson
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- S. H. Waddell
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- P. Tsokkou
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- N. T. Younger
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- A. Raven
- Cancer Research UK Beatson Institute
- S. R. Bhalla
- Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Centre for Cancer Science, Queen’s Medical Centre
- A. T. R. Noll
- Department of Surgery, Maastricht University
- S. W. Olde Damink
- Department of Surgery, Maastricht University
- F. G. Schaap
- Department of Surgery, Maastricht University
- P. Chen
- Department of Cell Biology, Emory University School of Medicine
- D. O. Bates
- Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Centre for Cancer Science, Queen’s Medical Centre
- J. M. Banales
- Biodonostia HRI, CIBERehd, Ikerbasque
- C. H. Dean
- National Heart and Lung Institute, Imperial College London
- D. J. Henderson
- Cardiovascular Research Centre, Institute of Genetic Medicine, Newcastle University
- O. J. Sansom
- Cancer Research UK Beatson Institute
- T. J. Kendall
- University of Edinburgh Centre for Inflammation Research
- L. Boulter
- MRC Human Genetics Unit, Institute for Genetic and Molecular Medicine
- DOI
- https://doi.org/10.1038/s41467-020-14283-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.
