Nature Communications (Nov 2017)

Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

  • Lee Schnaider,
  • Sayanti Brahmachari,
  • Nathan W. Schmidt,
  • Bruk Mensa,
  • Shira Shaham-Niv,
  • Darya Bychenko,
  • Lihi Adler-Abramovich,
  • Linda J. W. Shimon,
  • Sofiya Kolusheva,
  • William F. DeGrado,
  • Ehud Gazit

DOI
https://doi.org/10.1038/s41467-017-01447-x
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, but their antibacterial properties can be overlooked. Here the authors show the antibacterial activity of self-assembled diphenylalanine, which emerges as the minimal model for antibacterial supramolecular polymers.