Communications Biology (May 2022)

The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction

  • Divya Purushothaman,
  • Laura F. Bianchi,
  • Dmitry Penkov,
  • Alessandro Poli,
  • Qingsen Li,
  • Jelena Vermezovic,
  • Francesca M. Pramotton,
  • Ramveer Choudhary,
  • Fabrizio A. Pennacchio,
  • Elena Sommariva,
  • Marco Foiani,
  • Nils Gauthier,
  • Paolo Maiuri,
  • Francesco Blasi

DOI
https://doi.org/10.1038/s42003-022-03406-9
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction.