Communications Biology (Jun 2022)
Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors
- Yuko Makino,
- Chihiro Oe,
- Kazuya Iwama,
- Satoshi Suzuki,
- Akie Nishiyama,
- Kazuya Hasegawa,
- Haruka Okuda,
- Kazushige Hirata,
- Mariko Ueno,
- Kumi Kawaji,
- Mina Sasano,
- Emiko Usui,
- Toshiaki Hosaka,
- Yukako Yabuki,
- Mikako Shirouzu,
- Makoto Katsumi,
- Kazutaka Murayama,
- Hironori Hayashi,
- Eiichi N. Kodama
Affiliations
- Yuko Makino
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- Chihiro Oe
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- Kazuya Iwama
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- Satoshi Suzuki
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- Akie Nishiyama
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- Kazuya Hasegawa
- Structural Biology Division, Japan Synchrotron Radiation Research Institute
- Haruka Okuda
- Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University
- Kazushige Hirata
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- Mariko Ueno
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- Kumi Kawaji
- Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University
- Mina Sasano
- Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University
- Emiko Usui
- Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University
- Toshiaki Hosaka
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Yukako Yabuki
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Mikako Shirouzu
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Makoto Katsumi
- Division of Clinical Laboratory, Department of Clinical Laboratory Medicine, Tohoku University Hospital
- Kazutaka Murayama
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Hironori Hayashi
- Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University
- Eiichi N. Kodama
- Department of Infectious Diseases, Tohoku University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-03555-x
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
Structural and biophysical studies of the inhibition of bacterial serine hydroxymethyltransferase (SHMT) by a human SHMT inhibitor used for cancer therapy, (+)-SHIN-1, identify SHMT as a potent antibacterial target.
