Tumor Suppression by p53: Is Apoptosis Important or Not?
Hestia Mellert,
Joaquín M. Espinosa
Affiliations
Hestia Mellert
Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
Joaquín M. Espinosa
Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function.
