Antibiotic Resistant Pattern in Escherichia Coli Derived from Outpatients and Inpatients with Urinary Tract Infections in Alzahra Hospital, Isfahan, Iran

Abstract

- Background: Urinary tract infection (UTI) is one of the most frequent infectious diseases and can occur in all age groups. Due to various complications of urinary tract infections, timely and proper treatment seems important. This study aimed to assess the antibiotic resistant pattern in Escherichia coli derived from outpatients and inpatients with urinary tract infections in Alzahra Hospital, Isfahan, Iran Methods: 135 isolates of Escherichia coli (from urine) were collected from September to February, 2013, from Alzahra Hospital (Isfahan, Iran). The samples were cultured on nutrient agar, Mac Conkey agar, Blood agar and Eosin methylene blue (EMB) agar. Bacterial susceptibility to antimicrobial agents was determined using Kirby-Bauer disk diffusion method as recommended by the Clinical and Laboratory Standards Institute (CLSI) guidelines. Findings: Among 135 Escherichia coli isolates, 91 isolates belonged to outpatients and 44 to inpatients. In total, 68% of the participants were women. Antibiotic resistance to ampicillin, ceftazidime, nalidixic acid and trimethoprim/sulfamethoxazole were higher than 50%. The rates of resistance to ceftazidime, ampicillin, trimethoprim/sulfamethoxazole, cefepime, and cefotaxime in outpatients were higher than in inpatients. Conclusion: Due to excessive use of antibiotics and increasing antibiotic resistance, it is necessary to perform antibiotic resistance tests routinely in laboratories.

Keywords

• Antimicrobial resistance
• Escherichia coli
• Urinary tract infections