Asymmetrical Biantennary Glycans Prepared by a Stop-and-Go Strategy Reveal Receptor Binding Evolution of Human Influenza A Viruses

• Shengzhou Ma,
• Lin Liu,
• Dirk Eggink,
• Sander Herfst,
• Ron A. M. Fouchier,
• Robert P. de Vries,
• Geert-Jan Boons

Affiliations

Shengzhou Ma

Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States

Lin Liu

Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States

Dirk Eggink

Department of Medical Microbiology and Infection prevention, Laboratory of Applied Evolutionary Biology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands

Sander Herfst

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands

Ron A. M. Fouchier

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands

Robert P. de Vries

Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

Geert-Jan Boons

Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States