Nature Communications (Aug 2017)
Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
- Monika Haemmerle,
- Morgan L. Taylor,
- Tony Gutschner,
- Sunila Pradeep,
- Min Soon Cho,
- Jianting Sheng,
- Yasmin M. Lyons,
- Archana S. Nagaraja,
- Robert L. Dood,
- Yunfei Wen,
- Lingegowda S. Mangala,
- Jean M. Hansen,
- Rajesha Rupaimoole,
- Kshipra M. Gharpure,
- Cristian Rodriguez-Aguayo,
- Sun Young Yim,
- Ju-Seog Lee,
- Cristina Ivan,
- Wei Hu,
- Gabriel Lopez-Berestein,
- Stephen T. Wong,
- Beth Y. Karlan,
- Douglas A. Levine,
- Jinsong Liu,
- Vahid Afshar-Kharghan,
- Anil K. Sood
Affiliations
- Monika Haemmerle
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Morgan L. Taylor
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Tony Gutschner
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Sunila Pradeep
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Min Soon Cho
- Section of Benign Hematology, The University of Texas MD Anderson Cancer Center
- Jianting Sheng
- Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston Methodist Hospital
- Yasmin M. Lyons
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Archana S. Nagaraja
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Robert L. Dood
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Yunfei Wen
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Lingegowda S. Mangala
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Jean M. Hansen
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Rajesha Rupaimoole
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Kshipra M. Gharpure
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Cristian Rodriguez-Aguayo
- Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
- Sun Young Yim
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Ju-Seog Lee
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Cristina Ivan
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Wei Hu
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Gabriel Lopez-Berestein
- Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
- Stephen T. Wong
- Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston Methodist Hospital
- Beth Y. Karlan
- Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Geffen School of Medicine at UCLA
- Douglas A. Levine
- Department of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Centre, NYU Langone Medical Center
- Jinsong Liu
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Vahid Afshar-Kharghan
- Section of Benign Hematology, The University of Texas MD Anderson Cancer Center
- Anil K. Sood
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-017-00411-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.
