Somatostatin receptor 1,2 and 5 activation leads to C6 glioma growth arrest in vitro and in vivo; analysis of the intracellular pathways involved

Abstract

We report that somatostain receptor (SSTR) 1,2 and 5 activation by selective agonista, cause C6 cell growth arrest through PTPn-dependent dephosphorylation of ERK1/2 in vitro and after xenografting in nude mice. Individual SSTR agonist desplayed different efficacy and potecy showing partial synergism by combined treatment. Since most tumor cells express multiple SSTRs, the activtion of all the subtypes may grant a better control of cancer growth.

Keywords

• somatostatin, somatostatine receptor, gliomas