The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures

Yu-Nuo Wu; Xing Su; Xue-Qin Wang; Na-Na Liu; Zhou-Wei Xu; Zhou-Wei Xu

doi:10.3389/fonc.2023.1231875

Frontiers in Oncology (Jul 2023)

The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures

Yu-Nuo Wu,
Xing Su,
Xue-Qin Wang,
Na-Na Liu,
Zhou-Wei Xu,
Zhou-Wei Xu

Affiliations

Yu-Nuo Wu: Department of Clinical Medical, the First Clinical Medical College of Anhui Medical University, Hefei, Anhui, China
Xing Su: Department of Clinical Medical, the First Clinical Medical College of Anhui Medical University, Hefei, Anhui, China
Xue-Qin Wang: Department of Clinical Medical, the First Clinical Medical College of Anhui Medical University, Hefei, Anhui, China
Na-Na Liu: Department of Emergency Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Zhou-Wei Xu: Department of Emergency Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Zhou-Wei Xu: Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, Anhui, China

DOI: https://doi.org/10.3389/fonc.2023.1231875
Journal volume & issue: Vol. 13

Abstract

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PLC-β is widely distributed in eukaryotic cells and is the key enzyme in phosphatidylinositol signal transduction pathway. The cellular functions regulated by its four subtypes (PLC-β1, PLC-β2, PLC-β3, PLC-β4) play an important role in maintaining homeostasis of organism. PLC-β and its related signals can promote or inhibit the occurrence and development of cancer by affecting the growth, differentiation and metastasis of cells, while targeted intervention of PLC-β1-PI3K-AKT, PLC-β2/CD133, CXCR2-NHERF1-PLC-β3, Gαq-PLC-β4-PKC-MAPK and so on can provide new strategies for the precise prevention and treatment of malignant tumors. This paper reviews the mechanism of PLC-β in various tumor cells from four aspects: proliferation and differentiation, invasion and metastasis, angiogenesis and protective measures.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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