Raman and Infrared spectroscopies and X-ray diffraction data on bupivacaine and ropivacaine complexed with 2-hydroxypropylâβâcyclodextrin
Murillo L. Martins,
Juergen Eckert,
Henrik Jacobsen,
Everton C. dos Santos,
Rosanna Ignazzi,
Daniele Ribeiro de Araujo,
Marie-Claire Bellissent-Funel,
Francesca Natali,
Michael Marek Koza,
Aleksander Matic,
Eneida de Paula,
Heloisa N. Bordallo
Affiliations
Murillo L. Martins
Niels Bohr Institute, University of Copenhagen, Universitetsparken 5 DK-2100, Copenhagen, Denmark; Corresponding author.
Juergen Eckert
Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, United States; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, United States
Henrik Jacobsen
Niels Bohr Institute, University of Copenhagen, Universitetsparken 5 DK-2100, Copenhagen, Denmark
Everton C. dos Santos
Niels Bohr Institute, University of Copenhagen, Universitetsparken 5 DK-2100, Copenhagen, Denmark; Department of Physics, Norwegian University of Science and Technology (NTNU), Høgskoleringen 5 NO-7491, Trondheim, Norway
Rosanna Ignazzi
Niels Bohr Institute, University of Copenhagen, Universitetsparken 5 DK-2100, Copenhagen, Denmark
Institute of Materials, Research National Council (CNR-IOM), Italy; Institut Laue-Langevin, BP 156, F-38042 Grenoble Cedex 9, France
Michael Marek Koza
Institut Laue-Langevin, BP 156, F-38042 Grenoble Cedex 9, France
Aleksander Matic
Department of Applied Physics, Chalmers University of Technology, SE-41296 Göteborg, Sweden
Eneida de Paula
Department of Biochemistry and Tissue Biology, State University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil
Heloisa N. Bordallo
Niels Bohr Institute, University of Copenhagen, Universitetsparken 5 DK-2100, Copenhagen, Denmark; European Spallation Source ESS AB, P.O. Box 176, SE-22100 Lund, Sweden
The data presented in this article are related to the research article entitled âProbing the dynamics of complexed local anesthetics via neutron scattering spectroscopy and DFT calculations (http://dx.doi.org/10.1016/j.ijpharm.2017.03.051)â (Martins et al., 2017) [1]. This work shows the molecular and structural behavior of the local anesthetics (LAs) bupivacaine (BVC, C18H28N2O) and ropivacaine (RVC, C17H26N2O) before and after complexation with the water-soluble oligosaccharide 2-hydroxypropylâβâcyclodextrin (HP-β-CD).
