INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sandipan Brahma; Maheshi I. Udugama; Jongseong Kim; Arjan Hada; Saurabh K. Bhardwaj; Solomon G. Hailu; Tae-Hee Lee; Blaine Bartholomew

doi:10.1038/ncomms15616

Nature Communications (Jun 2017)

INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sandipan Brahma,
Maheshi I. Udugama,
Jongseong Kim,
Arjan Hada,
Saurabh K. Bhardwaj,
Solomon G. Hailu,
Tae-Hee Lee,
Blaine Bartholomew

Affiliations

Sandipan Brahma: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Maheshi I. Udugama: Graduate Program in Molecular Biology, Microbiology and Biochemistry, Southern Illinois University School of Medicine
Jongseong Kim: Department of Chemistry and the Huck Institutes of the Life Sciences, The Pennsylvania State University
Arjan Hada: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Saurabh K. Bhardwaj: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Solomon G. Hailu: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Tae-Hee Lee: Department of Chemistry and the Huck Institutes of the Life Sciences, The Pennsylvania State University
Blaine Bartholomew: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms15616
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Chromatin remodellers usually mobilize or disassemble nucleosomes by translocating along the nucleosomal DNA at the H3-H4 interface. Here, the authors provide evidence chromatin remodeller INO80 translocates along DNA at the H2A-H2B interface and displaces DNA from the surface of H2A-H2B.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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