Enzymaturia as a Marker of Renal Dysfunction in Full-Term Newborns with Perinatal Pathology

Abstract

Objective — to study the condition of glomerular and tubular functions in full-term newborns with perinatal pathology on the basis of detection of activity of enzymes contained in urine. Materials and methods. We have examined 46 children with clinical signs of perinatal pathology of a moderate severity and relatively preserved renal functions (I group), 30 critically ill children with changes of the renal functions (IIA group), 22 critically ill children with manifestations of acute renal injury (IIB group) and 45 healthy newborns (ІІІ group). The levels of creatinine and enzymatic activity were detected in the urine: cholinesterase, aspartate and alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transpeptidase. Results. The I group of children were characterized by preservation of renal filtration function against the background of laboratory signs of disorders of the tubular function. In the urine of children from the IIA group, there were found different changes in the activity of most enzymes. Formation of acute kidney injury in children from IIB group is associated with highest activity of glomerular and tubular enzymes. Conclusion. Detection of enzymaturia in full-term newborns with clinical signs of perinatal pathology of various severities enables to estimate the depth of disorders of the structural and functional elements of the kidneys and localization of the pathological process.

Keywords

• newborns
• perinatal pathology
• enzymaturia