Regioselective hydroamination of diphenylphosphorylallenes to synthesize β-aminophosphine oxides

Abstract

The regioselective hydroamination of diphenylphosphorylallenes has been developed using secondary amines as the amination reagents. This reaction protocol could be realized under ligand and transition metal-free conditions at room temperature and is tolerated to a diverse range of diphenylphosphorylallenes and amine substrates, affording a series of β-aminophosphine oxides in good yields after the reduction of the enamine intermediates. Keywords: Hydroamination, Allenes, β-Aminophosphine oxides