One-pot, simple and efficient synthesis of novel bioactive 4-aryl-1,2-dihydro-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxopyridin-3-carbonitriles via multi-component approach

Abstract

Quantitative multicomponent cyclocondensation of 3-acetyl-4-hydroxycoumarine with ethyl cyanoacetate and aryldehydes has been carried out in ammonium acetate, at reflux. The optimization details of the developed novel protocol are recorded. The structure of newly synthesized compounds have been characterized by spectroscopic data (elemental analysis, IR and 1H NMR spectroscopic studied). Antimicrobial properties of the novel coumarins derivatives 3 are investigated. The acetylcholinesterase inhibition activity (AChEI) was tested for all compounds, and the 3b shows the highest AChEI activity with 48.25% of inhibition. Keywords: Multicomponent reaction, 4-Hydroxycoumarin, Ethyl cyanoacetate, Antibacterial and acetylcholinesterase inhibition activities