The Role of Chemokines in Cervical Cancers

Fabian Garrido; Carl Mathis Wild; Johanna Mittelberger; Franziska Dobler; Mariella Schneider; Nadine Ansorge; Melitta Köpke; Annamarie Strieder; Nina Ditsch; Udo Jeschke; Christian Dannecker

doi:10.3390/medicina57111141

Medicina (Oct 2021)

The Role of Chemokines in Cervical Cancers

Fabian Garrido,
Carl Mathis Wild,
Johanna Mittelberger,
Franziska Dobler,
Mariella Schneider,
Nadine Ansorge,
Melitta Köpke,
Annamarie Strieder,
Nina Ditsch,
Udo Jeschke,
Christian Dannecker

Affiliations

Fabian Garrido: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Carl Mathis Wild: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Johanna Mittelberger: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Franziska Dobler: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Mariella Schneider: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Nadine Ansorge: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Melitta Köpke: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Annamarie Strieder: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Nina Ditsch: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Udo Jeschke: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany
Christian Dannecker: Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany

DOI: https://doi.org/10.3390/medicina57111141
Journal volume & issue: Vol. 57, no. 11
p. 1141

Abstract

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Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.

Published in Medicina

ISSN: 1010-660X (Print); 1648-9144 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: https://www.mdpi.com/journal/medicina

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Abstract

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