Myasthenia gravis with tongue muscle atrophy: A case series
Xue-Lu Zhao,
Yue-Liang Zheng,
Chun-Lin Yang,
Jun-Yan Wang,
Ying Liu,
Tong Du,
Ze-Yu Zhao,
Rui-Sheng Duan,
Xiao-Li Li
Affiliations
Xue-Lu Zhao
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China
Yue-Liang Zheng
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China
Chun-Lin Yang
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China; Shandong Institute of Neuroimmunology, Jinan, 250014, PR China; Shandong Provincial Medicine and Health Key Laboratory of Neuroimmunology, Jinan, 250014, PR China
Jun-Yan Wang
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China
Ying Liu
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China; Shandong Institute of Neuroimmunology, Jinan, 250014, PR China; Shandong Provincial Medicine and Health Key Laboratory of Neuroimmunology, Jinan, 250014, PR China
Tong Du
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China; Shandong Institute of Neuroimmunology, Jinan, 250014, PR China; Shandong Provincial Medicine and Health Key Laboratory of Neuroimmunology, Jinan, 250014, PR China
Ze-Yu Zhao
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China
Rui-Sheng Duan
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China; Shandong Institute of Neuroimmunology, Jinan, 250014, PR China; Shandong Provincial Medicine and Health Key Laboratory of Neuroimmunology, Jinan, 250014, PR China
Xiao-Li Li
Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, PR China; Shandong Institute of Neuroimmunology, Jinan, 250014, PR China; Shandong Provincial Medicine and Health Key Laboratory of Neuroimmunology, Jinan, 250014, PR China; Corresponding author. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Neuroimmunology, Shandong Provincial Medicine and Health Key Laboratory of Neuroimmunology, No. 16766, Jingshi Road, Jinan, 250014, PR China.
Here, we presented 6 patients who were admitted to our institution and diagnosed as myasthenia gravis (MG) with tongue muscle atrophy. All these 6 patients developed symptoms of bulbar muscle weakness in acetylcholine receptor antibodies positive MG (AChR-MG) (3/6), muscle-specific receptor tyrosine kinase antibodies positive MG (MuSK-MG) (1/6), and sero-negative MG (2/6). Most of patients had “triple-furrowed” tongue except for patient 2 with irregular atrophy of tongue muscle. Tongue muscle atrophy occurs in patients with MuSK-MG, AChR-MG, and sero-negative MG. Atrophied tongue muscles of five patients with MG were reversible after immunotherapy.
