Nature Communications (Nov 2018)

Integrative epigenetic taxonomy of primary prostate cancer

  • Suzan Stelloo,
  • Ekaterina Nevedomskaya,
  • Yongsoo Kim,
  • Karianne Schuurman,
  • Eider Valle-Encinas,
  • João Lobo,
  • Oscar Krijgsman,
  • Daniel Simon Peeper,
  • Seiwon Laura Chang,
  • Felix Yi-Chung Feng,
  • Lodewyk Frederik Ary Wessels,
  • Rui Henrique,
  • Carmen Jerónimo,
  • Andries Marinus Bergman,
  • Wilbert Zwart

DOI
https://doi.org/10.1038/s41467-018-07270-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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The Androgen Receptor (AR) is the main driver of prostate cancer and functions in conjunction with chromatin modifications. Here, the authors comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with ChIP-sequencing for AR and the active histone marks H3K27ac, H3K4me3 and repressive mark H3K27me3.