Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Manuel Blandino-Rosano; Rebecca Barbaresso; Margarita Jimenez-Palomares; Nadejda Bozadjieva; Joao Pedro Werneck-de-Castro; Masayuki Hatanaka; Raghavendra G. Mirmira; Nahum Sonenberg; Ming Liu; Markus A. Rüegg; Michael N. Hall; Ernesto Bernal-Mizrachi

doi:10.1038/ncomms16014

Nature Communications (Jul 2017)

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Manuel Blandino-Rosano,
Rebecca Barbaresso,
Margarita Jimenez-Palomares,
Nadejda Bozadjieva,
Joao Pedro Werneck-de-Castro,
Masayuki Hatanaka,
Raghavendra G. Mirmira,
Nahum Sonenberg,
Ming Liu,
Markus A. Rüegg,
Michael N. Hall,
Ernesto Bernal-Mizrachi

Affiliations

Manuel Blandino-Rosano: Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of Medicine
Rebecca Barbaresso: Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical Center
Margarita Jimenez-Palomares: Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical Center
Nadejda Bozadjieva: Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical Center
Joao Pedro Werneck-de-Castro: Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of Medicine
Masayuki Hatanaka: Department of Pediatrics, Indiana University School of Medicine
Raghavendra G. Mirmira: Department of Pediatrics, Indiana University School of Medicine
Nahum Sonenberg: Department of Biochemistry, McGill University
Ming Liu: Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical Center
Markus A. Rüegg: Biozentrum, University of Basel
Michael N. Hall: Biozentrum, University of Basel
Ernesto Bernal-Mizrachi: Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of Medicine

DOI: https://doi.org/10.1038/ncomms16014
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and insulin processing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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