Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

• Sjoerd H van der Burg,
• Thomas Höllt,
• Ziena Abdulrahman,
• Marieke E Ijsselsteijn,
• Noel F C C de Miranda,
• Dana A M Mustafa,
• Marij J P Welters,
• Zlatko Trajanoski,
• Saskia J Santegoets,
• Pornpimol Charoentong,
• Gregor Sturm,
• Antonios Somarakis,
• Francesca Finotello,
• Sylvia L van Egmond

Affiliations

Sjoerd H van der Burg

Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands

Thomas Höllt

5 Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands

Ziena Abdulrahman

Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands

Marieke E Ijsselsteijn

3 Pathology, Leiden University Medical Center, Leiden, The Netherlands

Noel F C C de Miranda

Pathology, Leiden University Medical Centre, Leiden, The Netherlands

Dana A M Mustafa

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands

Marij J P Welters

Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands

Zlatko Trajanoski

Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria

Saskia J Santegoets

Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands

Pornpimol Charoentong

Department of Medical Oncology and National Center for Tumor Diseases, University Hospital Heidelberg, Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany

Gregor Sturm

Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria

Antonios Somarakis

4Leiden University Medical Center, Leiden, Netherlands

Francesca Finotello

Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria

Sylvia L van Egmond

Otolaryngology, Leiden University Medical Center, Leiden, The Netherlands