Urology Journal (Sep 2010)

Safety and Efficacy of Clomiphene Citrate and L-Carnitine in Idiopathic Male Infertility: A Comparative Study

  • Mahmoudreza Moradi,1 ,1 ,1 ,2 ,1 ,3 4,
  • Asaad Moradi,
  • Mohsen Alemi,
  • Hassan Ahmadnia,
  • Hossein Abdi,
  • Alireza Ahmadi,
  • Shahrzad Bazargan-Hejazi

Journal volume & issue
Vol. 7, no. 3
pp. 188 – 193

Abstract

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PURPOSE: To compare the effects of L-carnitine with clomiphene citrate in idiopathic infertile men. MATERIALS AND METHODS: Fifty-two men with idiopathic infertility were recruited in this randomized controlled trial. They were randomly assigned into 2 treatment groups, group 1 (n = 20) and group 2 (n = 32), who received L-carnitine 25 mg/day and clomiphene citrate 2 gr/day, respectively, for a period of 3 months. RESULTS: Comparing the effect of L-carnitine and clomiphene on sperm parameters before and after the treatment, both medications had influence on sperm count and motility (P = .01). L-carnitine significantly increased the semen volume (P = .001), while clomiphene citrate was significantly associated with the motility percentage and normal morphology (P = .008). CONCLUSION: It seems that the use of clomiphene citrate and L-carnitine, either individually or in combination, as the first step of idiopathic maleinfertility treatment is reasonable, safe, and effective.

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