Research progress on the correlation between type Ⅱ inflammatory cytokines and pemphigus

Abstract

Pemphigus is a chronic autoimmune bullous skin disease that affects the skin and/or mucous membranes. The pathogenesis of pemphigus is closely associated with the formation of autoantibodies against desmoglein, involving B cell-mediated humoral immunity and T cell-mediated cellular immunity. Cytokines play a role in the immune response. Therefore, it is of great importance to explore the role of cytokines in the pathogenesis of pemphigus. This article reviews the association of Th2 cells and their cytokines, including IL-4, IL-5, IL-6, IL-10, IL-13 and IL-31, with the onset of pemphigus, thereby unraveling the pivotal role of type Ⅱ inflammatory responses in the pathogenesis of pemphigus.

Keywords

• pemphigus
• autoimmune bullous skin disease
• th2 cells
• type ⅱ inflammatory responses