Exploring the potential of microfluidics for next-generation drug delivery systems
Gargi Bhattacharjee,
Nisarg Gohil,
Malvika Shukla,
Swati Sharma,
Indra Mani,
Alok Pandya,
Dinh-Toi Chu,
Nhat Le Bui,
Yen-Vy Nguyen Thi,
Khushal Khambhati,
Rupesh Maurya,
Suresh Ramakrishna,
Vijai Singh
Affiliations
Gargi Bhattacharjee
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, India
Nisarg Gohil
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, India
Malvika Shukla
Department of Biotechnology and Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat 382426, India
Swati Sharma
Centre of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, University of Münster, Münster, Germany
Indra Mani
Department of Microbiology, Gargi College, University of Delhi, New Delhi, India
Alok Pandya
Department of Biotechnology and Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat 382426, India
Dinh-Toi Chu
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam
Nhat Le Bui
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam
Yen-Vy Nguyen Thi
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam
Khushal Khambhati
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, India
Rupesh Maurya
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, India
Suresh Ramakrishna
College of Medicine, Hanyang University, Seoul, South Korea; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea
Vijai Singh
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana 382715, Gujarat, India; Corresponding author.
The platform of microfluidics offers a precise control and manipulation over fluids at a small scale and therefore has gained much attention in recent times. This topic is currently applied to automation and high-throughput analysis in several areas, including extraction of DNA, RNA and proteins, gene identification, gene assembly, cloning, single-cell analysis, organs grown on chips, PCR, drug screening, toxicity testing and drug delivery. Conventional methods used for drug delivery are sometimes non-targeted leading to loss of administered drugs and reduced drug effectiveness. Recent advances in microfluidics allow precise dose-dependent delivery of a drug to a targeted location. Several microfluidics designs have been implemented to improve the precision of treatment in clinics. This review highlights currently available tools in microfluidics, designs for drug carriers, delivery methods, robotics and artificial intelligence in the field of microfluidics.
