This paper presents an experimental test room in a curtain wall building where an innovative monitoring and control system was implemented and tested. The proposed solution is composed by an IR-based comfort sensor that measures the PMV (Predicted Mean Vote) index for 2 room’s sub-zones and provides the optimal air temperature set-points. The overall control system includes a distributed sensors and actuators network, also embedded into the façade modules, to measure indoor and outdoor parameters and to regulate fan-coils, windows opening and shadings with a sub-zonal approach. Initial results turn out to provide an energy saving of about 20% with an improvement of thermal/visual comfort and IAQ conditions.