Glycosylated haemoglobin values of alloxan-induced diabetic rats treated with graded doses of Cussonia arborea extract

Abstract

This study investigated glycosylated haemoglobin values and fasting blood glucose (FBG) levels of diabetic rats treated with methanol extract of Cussonia arborea. A total of 72 male wistar rats were assigned into 6 groups of 12 rats per group. Groups 1–5 rats were made diabetic by intraperitoneal injection of alloxan monohydrate at the dose of 160 mg/kg and treated with 62.5, 125, 250 mg/kg of the extracts, 2 mg/kg glibenclamide and 10 ml/kg distilled water (DW), respectively, while the non-diabetic group 6 rats received 10 ml/kg DW and served as normal control rats. The treatment was daily through the oral route for 84 days. The glycosylated haemoglobin values were measured on days 42, 56 and 84 post treatment while the FBG levels were determined on 2 weeks interval post treatment till the end of the experiment. The mean FBG level of rats treated with 125 mg/kg of the extract showed the most significant reduction (p < .05) in FBG from 315.33 ± 10.08 mg/dl to 93.00 ± 8.50 mg/dl and equally ameliorated haemoglobin glycosylation when compared to the negative control group. It was concluded that the methanol extract of C.arborea, at the dose of 125 mg/kg mitigated glycosylation of haemoglobin.

Keywords

• Glycosylated haemoglobin
• Cussonia arborea
• fasting blood glucose