Frontiers in Physiology (Aug 2020)
Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
- Zhenying Zuo,
- Kaipeng Jing,
- Kaipeng Jing,
- Hongluan Wu,
- Hongluan Wu,
- Shujun Wang,
- Shujun Wang,
- Lin Ye,
- Zhihang Li,
- Chen Yang,
- Chen Yang,
- Qingjun Pan,
- Qingjun Pan,
- Wei Jing Liu,
- Wei Jing Liu,
- Wei Jing Liu,
- Hua-feng Liu,
- Hua-feng Liu
Affiliations
- Zhenying Zuo
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Kaipeng Jing
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Kaipeng Jing
- Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Hongluan Wu
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Hongluan Wu
- Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Shujun Wang
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Shujun Wang
- Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Lin Ye
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Zhihang Li
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Chen Yang
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Chen Yang
- Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Qingjun Pan
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Qingjun Pan
- Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Wei Jing Liu
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Wei Jing Liu
- Key Laboratory of Chinese Internal Medicine, Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China
- Wei Jing Liu
- Renal Research Institution of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China
- Hua-feng Liu
- Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Hua-feng Liu
- Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- DOI
- https://doi.org/10.3389/fphys.2020.00935
- Journal volume & issue
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Vol. 11
Abstract
Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN).
Keywords
