Nature Communications (Nov 2019)
Modular actin nano-architecture enables podosome protrusion and mechanosensing
- Koen van den Dries,
- Leila Nahidiazar,
- Johan A. Slotman,
- Marjolein B. M. Meddens,
- Elvis Pandzic,
- Ben Joosten,
- Marleen Ansems,
- Joost Schouwstra,
- Anke Meijer,
- Raymond Steen,
- Mietske Wijers,
- Jack Fransen,
- Adriaan B. Houtsmuller,
- Paul W. Wiseman,
- Kees Jalink,
- Alessandra Cambi
Affiliations
- Koen van den Dries
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Leila Nahidiazar
- Division of Cell Biology, The Netherlands Cancer Institute
- Johan A. Slotman
- Department of Pathology, Optical imaging center Erasmus MC
- Marjolein B. M. Meddens
- Department of Physics and Astronomy and Department of Pathology, University of New Mexico
- Elvis Pandzic
- Biomedical Imaging Facility, Mark Wainwright Analytical Centre, University of New South Wales
- Ben Joosten
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Marleen Ansems
- Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center
- Joost Schouwstra
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Anke Meijer
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Raymond Steen
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Mietske Wijers
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Jack Fransen
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Adriaan B. Houtsmuller
- Department of Pathology, Optical imaging center Erasmus MC
- Paul W. Wiseman
- Departments of Physics and Chemistry, McGill University Otto Maass (OM)
- Kees Jalink
- Division of Cell Biology, The Netherlands Cancer Institute
- Alessandra Cambi
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-13123-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Podosomes are actin-based protrusions used by cells for invasion and local degradation but the structure underlying their protrusiveness and mechanosensitivity is unclear. Here, the authors report that podosomes have a modular actin nano-architecture whose organization differs on stiff or soft substrates.
